Participants sought for clinical trial in Haywood County in affiliation with Wake Forest University

Do you have knee pain and are overweight? 

If so you may qualify to participate in the Weight Loss and Exercise for Communities with Arthritis in North Carolina (WE-CAN) clinical trial.  Wake Forest University received $6 million in grant funding to enable health and science researchers to further study knee osteoarthritis and successful treatment measures in community settings.

Haywood County was selected as one of the three counties in the study.

What is the study about?
Obesity is a modifiable risk factor for knee osteoarthritis (OA), and weight loss is an effective non-pharmacologic treatment to reduce pain.  This study aims to develop and to demonstrate the effectiveness of a systematic, practical, cost-effective diet-induced weight loss and exercise intervention over an 18 month period that communities can implement to reduce pain and improve other clinical outcomes in knee osteoarthritis patients.

You may qualify if you are:

  • Overweight

  • At least 50 years old

  • Have knee pain on most days of the week

The 18-month program may include healthy lifestyle and guidance programs or supervised exercise and weight loss program. 

The Haywood County program is directed by Dr. Kate Queen of Mountain Medical Associates 

To find out more about the study and
requirements for participation please contact us:

or call  828.558.0208


Leigh Callahan, Ph.D. Conducts Radio Interview Regarding Arthritis Clinical Trial in NC 

Medical research conducted in controlled environments has repeatedly proven that weight loss and exercise can offer significant benefits such as pain reduction for many people with osteoarthritis (OA), including knee OA. But researchers want to know more about how well these kinds of programs work (and can be optimized) in “real world,” community settings. Arthritis researcher Leigh Callahan, PhD, with the UNC Thurston Arthritis Research Center is leading a clinical trial in Johnston, Forsythe and Haywood Counties in NC. To listen to the radio interview, click here.

What is a clinical trial?

Clinical trials are research studies in which people help medical professionals find ways to improve health. Each study tries to answer specific scientific questions and is designed to find safe and effective ways to better prevent, diagnose, and/or treat disease. Before they can begin, all clinical trials must go through a rigorous review process conducted by the Wake Forest University Health Sciences Institutional Review Board to insure that the safety, rights and welfare of human subjects are protected.

Why would I want to consider participating in a clinical trial?

As a volunteer in a clinical trial, you have the opportunity to be involved in important research that may bring about advances in science and health care which will have a significant public health impact. 

Why is this important?
Many physicians who treat people with knee OA have no practical means to implement weight loss and exercise treatments. This study is significant in that it will test the effectiveness of a long-awaited and much needed community program that will serve as a blueprint for clinicians and public health officials in urban and rural communities to implement a weight loss and exercise program designed to reduce knee pain and improve other clinical outcomes in overweight and obese adults with knee OA.

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